The use of regular, long-term aspirin and non-steroidal anti-inflammatory drugs reduces the risk associated with colorectal cancer, according to a new study. However, the use of aspirin for chemoprevention of colorectal cancer may require using the drug at doses that are higher than recommended over a long period of time, which may cause serious side effects including gastrointestinal bleeding. Patients need to talk to their doctor to discuss risks vs. benefits.