Scientists have completed the first major review of diagnostic methods and treatments for a rapidly evolving virus that causes hand, foot and mouth disease in children. The virus, called enterovirus 71, is closely related to poliovirus, and was first detected in California in the 1960s. Since then the virus has spread across Asia, affecting mostly children and some adults. Serious cases of the disease can include neurological disorders such as meningitis, paralysis and encephalitis.