Researchers have uncovered a novel association between two fungal recognition receptors on the surface of certain immune cells, called macrophages. The interaction of these receptors (dectin-1 and galectin-3) sheds new light on how the innate immune system discriminates between non-pathogenic and pathogenic fungi. Invasive fungal infections are a rising source of morbidity and mortality in healthy individuals, as well as in patients suffering from chronic diseases, such as cancer or AIDS.