The latest advance in solid-state nanopore sensors — devices that are made with standard tools of the semiconductor industry yet can offer single-molecule sensitivity for label-free protein screening — expands their bag of tricks through bionanotechnology. Researchers have enhanced the capabilities of solid-state nanopores by fitting them with cover plates made of DNA. These nanoscale cover plates, with central apertures tailored to various “gatekeeper” functions, are formed by so-called DNA origami techniques.