Scientists discovered a new strategy to help CF and COPD patients clear the thick and sticky mucus clogging their lungs, leading to life-threatening infections. The report shows the “SPLUNC1” protein and its derivative peptides may help thin mucus by affecting the epithelial sodium channel. Along with its implications for cystic fibrosis and COPD, the research enhances the understanding of hypertension due to its role in controlling blood pressure.