One in four human tumor presents genetic polymorphisms associated with increased risk of cancer that cause an epigenetic change that modifies the expression of neighboring genes. “This work represents a Herculean effort to analyze by bioinformatics a lot of biological information. To be exact, we have studied a million genetic changes in relation to half a million epigenetic changes in 3,500 tumors representing the thirteen most common cancers, including breast, lung and colon,” says the lead researcher.