There are over 650,000 cases of oral cancer each year, and esophageal cancer represents the sixth most common cause of cancer death in men. Research has shown that a protein that helps cells stick together is frequently absent or out of place in these cancers, but it’s unclear if its loss causes the tumors. The investigators report that mice engineered to lack this protein, called p120-catenin, in the oral-upper digestive tract develop squamous cell cancers.