The consequence of maternal exposure to a variety of potentially toxic agents during pregnancy remains the prime focus of concern in scientific endeavors and in society at large. However, there is now mounting evidence that paternal exposure can also adversely affect fetal and postnatal development of offspring and that this imprint can be expressed in subsequent generations. The reported impact on offspring outcome includes low birth weight; increase in childhood cancers; developmental, behavioral, endocrine abnormalities and cross-generational effects.