It is known that HIV-infected children who do not receive appropriate antiretroviral drugs experience immune depression, and may become susceptible to infectious diseases that would otherwise be prevented by childhood immunization. It is therefore important to find out to what extent HIV-infected children are able to generate adequate levels of antibodies following routine childhood immunizations. A new article describes the results of a cross-sectional study carried out amongst 18-36 month-old children born to HIV-infected mothers and living in Central Africa. The study suggested that immuno-suppressed HIV-infected children have a low persistence of antibodies to the vaccines of the Expanded Program on Immunization.