A new study suggests that antidepressants only benefit some, very severely depressed patients. “New generation” antidepressants, such as fluoxetine (Prozac) are widely prescribed for the treatment of clinical depression. However some studies have suggested that these drugs do not help the majority of depressed people get better by very much. Researchers looked at whether a patient’s response to antidepressant therapy depends on how badly depressed they are to start out with.