Tumor suppressor genes do not necessarily require both alleles to be knocked out before disease phenotypes are expressed. Only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer.
Tumor suppressor genes do not necessarily require both alleles to be knocked out before disease phenotypes are expressed. Only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer.