Scientists have discovered a novel signaling pathway between three organs — the gut, the brain, and the liver — which lowers blood sugar when activated. Researchers used a rat model to discover that fats can activate a subset of nerves in the intestine, which then send a signal to the brain and subsequently to the liver to lower glucose or sugar production. But eating a high-fat diet for just three days can interfere with this signal, disabling it so that it does not signal the other organs to lower blood glucose levels.