Liver cancer is the fifth most common cancer in the world with a poor prognosis. Recent data show the frequency of liver cancer in the U.S. overall is rising. Cancer chemoprevention is an active measure to limit/retard the progression and pathogenesis of malignancy. Herbal preparations constitute an important component of indigenous/traditional medicines. Scientists now report on the potential chemopreventive efficacy of an Indian medicinal plant Acanthus ilicifolius in preventing liver DNA damage and in remodeling hepatocellular malignant lesions in an animal model, which may have an ultimate benefit to human beings in near future.