By using computer simulations and modeling, researchers have determined how a pandemic influenza outbreak might travel through a city similar in size to Chicago, Ill. This information helped them to determine the preferred intervention strategy to contain a potential flu pandemic, including what people should do to decrease the likelihood of disease transmission. An outbreak in the US could be mitigated with prompt implementation of social-distancing measures combined with antiviral treatment and prophylaxis until a vaccine is available, the study suggests.