A new study found that anti-glycan antibodies were associated with celiac disease. Celiac patients with multiple anti-glycan antibodies of high titers had more frequently malabsorption than other symptoms. Contrary, presence of the anti-microbial antibodies did not show familial aggregation or association with mutations in NOD2/CARD15. Presence of anti-glycan antibodies in celiac disease is supposed secondary to the impaired gut barrier leading to sustained exposure to the gut microflora constituents via translocation.