“Superbugs” from the Burkholderia cepacia complex (Bcc) could affect treatment of cystic fibrosis (CF). Mannitol inhalation for CF works by attracting moisture into the lungs, thinning the mucus produced. Researchers report that when Bcc are grown on mannitol they produce exopolysaccharide which could contribute to the very problem that the mannitol therapy was designed to solve.