Researchers have developed a remarkable new method to precisely track transmission of MRSA from one person to another in a hospital setting. The method “zooms” from large-scale inter-continental transmission events to person-to-person infection of MRSA within a single hospital. The technique, which harnesses the latest high-throughput DNA sequencing technologies, helps researchers understand how strains spread so rapidly, and should lead to novel infection control strategies, not only for MRSA but also for other emerging superbugs.