Bloodstream infections in newborns can lead to serious complications with substantial morbidity and mortality. In recent years, antibiotic prophylaxis given to at-risk mothers has reduced the incidence of early-onset group B streptococcal infections among their babies. A new nationwide study shows the most frequent pathogens associated with sepsis are group B streptococci (GBS) in full-term infants and Escherichia coli in preterm infants. The study also found that infection rates in newborns increased with decreasing gestational age and birth weight.