Challenging risk assessment methods used for decades by toxicologists, a new review of the literature suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical toxicity, does not accurately mimic how humans are exposed to chemicals in everyday life. Oral gavage refers to the way researchers give chemicals to animals by putting a tube down their throats to deliver substances directly to the stomach. It has been used for decades and is the dosing scheme preferred for assessing potential toxicity of endocrine disrupting chemicals.